The primary transcripts, pre‐mRNAs, of almost all protein‐coding genes in higher eukaryotes contain multiple non‐coding intervening sequences, introns, which must be precisely removed to yield translatable mRNAs. The process of intron excision, splicing, takes place in a massive ribonucleoprotein complex known as the spliceosome. Extensive studies, both genetic and biochemical, in a variety of systems have revealed that essential components of the spliceosome include five small RNAs–U1, U2, U4, U5 and U6, each of which functions as a RNA, protein complex (...) called an snRNP (small nuclear ribonucleoprotein). In addition to snRNPs, splicing requires many non‐snRNP protein factors, the exact nature and number of which has been unclear. Technical advances, including new affinity purification methods and improved mass spectrometry techniques, coupled with the completion of many genome sequences, have now permitted a number of proteomic analyses of purified spliceosomes. These studies, recently reviewed by Jurica and Moore,1 reveal that the spliceosome is composed of as many as 300 distinct proteins and five RNAs, making it among the most complex macromolecular machines known. BioEssays 25:1147–1149, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Liberal democracy is today under unprecedented attack from both the left and the right. Offering a fresh and penetrating examination of how Leo Strauss understood the emergence of liberal democracy and what is necessary to sustain and elevate it, Leo Strauss on Modern Democracy, Technology, and Liberal Education explores Strauss' view of the intimate (and troubling) relation between the philosophic promotion of liberal democracy and the turn to the modern scientific-technological project of the 'conquest of nature'. Timothy W. Burns (...) explicates the political reasoning behind Strauss' recommendation of reminders of genuine political greatness within democracy over and against the failure of nihilistic youth to recognize it. Elucidating what Strauss envisaged by a liberally-educated sub-political or cultural-level aristocracy--one that could elevate and sustain liberal democracy--and the roles that both philosophy and divine-law traditions should have in that education, Burns also lays out Strauss' frequent (though often tacit) engagement with the thought of Heidegger on these issues." -- Page 4 of cover. (shrink)

This chapter introduces readers to the aims and scope of the book. Readers are given the social and scholarly context in which the book emerges. The introduction suggests that the history and philosophy of hospice care contain moral values that can be resonant or dissonant with larger social values, giving those who work in hospice organizations an important place in the national discussion about terminal care. Finally, it offers a brief explanation of the goals of each chapter in the book.

Throughout much of his long life, Kenneth Burke was recognized as a leading American intellectual, perhaps the most significant critic writing in English since Coleridge. From about 1950 on, rhetoricians in both English and speech began to see him as a major contributor to the New Rhetoric. But despite Burke's own claims to be writing philosophy and some notice from reviewers and critics that his work was philosophically significant, Timothy W. Crusius is the first to access his work as (...) philosophy. Crusius traces Burke's commitment and contributions to philosophy prior to 1945, from Counter-Statement through The Philosophy of Literary Form. While Burke might have been a late modernist thinker, Crusius shows that Burke actually starts from a position closely akin to such postmodern figures as Michel Foucault and Richard Rorty. Crusius then examines Burke's work from A Grammar of Motives up to his last published essays, drawing most heavily on A Rhetoric of Motives, The Rhetoric of Religion, and uncollected essays from the 1970s. This part concerns Burke's contributions to human activities always closely associated with rhetoric-hermeneutics, dialectic, and praxis. Burke's highly developed notion of our species as the "symbol-using animal," argues Crusius, draws together the various strands of his later philosophy—his concern with interpretation, with dialectic and dialogue, with a praxis devoted to awareness and control of the self-deceiving and potentially self-destructive motives inherent in language itself. (shrink)

ExcerptWhat is “the place of truth at the university”? This is more than a metaphysical question. To address it, this analysis first considers broader facets of this question and then examines more specific qualities in the concern with truth by focusing on how particular universities in the United States situate themselves with respect to this issue. Only by considering their everyday operations, as the contemporary creators and curators of the truths they tout in their workings today, can a more concrete (...) critical sense of this question be crafted. (shrink)

This study reassesses the concept of the Anthropocene as a new geological age as it is influencing contemporary debates in social theory. As a unit of geological time whose changes are allegedly caused, directly and indirectly, by human beings, this scientific concept challenges the existing constructions of theoretical binaries, such as nature/culture, environment/society, objectivity/subjectivity or happenstance/design, in social theory. The analysis suggests many understandings of the Anthropocene in social theory are politicized over-interpretations of natural events, and these moves appear to (...) be developing moral rhetorics of, and operational plans for, managing the Anthropocene to create specific outcomes for those who are the managers as well as the managed. The fact that human beings do not, in fact, have this measure of technical control is ignored by advocates of Anthropocenarian politics to advance their policy agendas. (shrink)

Previous research has linked the concept of number and other ordinal series to space via a spatially oriented mental number line. In addition, it has been shown that in visual scene recognition and production, speakers of a language with a left-to-right orthography respond faster to and tend to draw images in which the agent of an action is located to the left of the patient. In this study, we aim to bridge these two lines of research by employing a novel (...) method that measures the spatial bias produced by transitive sentences that use a wide variety of abstract and concrete verbs. Across four experiments, participants read sentences and then responded to probe words appearing on either the left or right sides of the screen. Probe words consisted of agents, patients, other words in the sentence, or newly encountered words. We found consistent lateral biases to responding to agents and patients, which appears to be independent of order of mention in the sentence but which does reflect a correspondence between position in the sentence and role in the causal sequence of the action. Our results also show that this spatial bias is driven by the use of the hands in two different ways: The left hand shows a greater sensitivity to the spatial effect than the right hand, and vocal responses produce no spatial effect. (shrink)

In Recovering the Ancient View of Founding, Timothy Caspar defends the influential political thinker Cicero and his philosophical dialogue De Legibus. Cicero and De Legibus have often been criticized as eclectic and mismatched parts stitched together. However, through close reading and robust scholarship, Caspar illuminates how De Legibus was in fact a unified and original work, and an important development of classical political philosophy.

A collection of essays by Timothy W. Luke discussing social and political issues related to ecology, environmentalism, ecocriticism, global climate change, and the Anthropocene.

SOME PHILOSOPHERS RESORT TO RELATIVE IDENTITY IN ORDER TO DEFEND THE CHRISTIAN DOCTRINE OF THE TRINITY AGAINST ACCUSATIONS OF INCOHERENCE: THEY CLAIM THAT FATHER, SON, AND HOLY SPIRIT ARE NUMERICALLY THE SAME DEITY BUT ALSO NUMERICALLY DISTINCT PERSONS. I ARGUE THAT THEIR CLAIM IS EITHER INCOHERENT OR IMPOSSIBLE TO MOTIVATE. I ALSO ARGUE THAT THE SOCIAL INTERPRETATION OF THE TRINITY, ACCORDING TO WHICH FATHER, SON, AND HOLY SPIRIT ARE DISTINCT "SIMPLICITER", IS NOT OBVIOUSLY UNORTHODOX.

_Brill's Companion to Leo Strauss’ Writings on Classical Political Thought_ offers clear, accessible essays to assist a new generation of readers in their introduction to Strauss’ writings on the ancients, and to deepen the understanding of those familiar with his work.

ExcerptWhat factors lead to any war being fought in a particular manner? How and why do those factors become institutionalized, or abandoned, as prime forms of war for typifying other armed conflicts in changing world orders? When and why do the prevailing parameters of world order shape the conduct of war? Questions about the forms of war became highly salient in 1945 when, by virtue of the United Nations Charter, “the peoples of the United Nations determined” to organize stronger institutions (...) for global governance with an elaborate apparatus of multiple functional agencies “to save succeeding generations from the scourge of war” by establishing conditions “under which justice and respect for the obligations arising from treaties and other sources of international law can be maintained” as well as to “promote social progress and better standards of life in larger freedom.”1. (shrink)

The article considers how the field of moral welfare and social work empowered religious women, and how these women met the challenge posed by Yeo, ‘to find ways of breaking the material, representational and psychic chains of subordination without reassembling them at the same time in a different form’. Based on an examination of the archival records and reports of these moral welfare organizations the article argues that the spiritual dimension of moral welfare work provided particular resources that empowered women (...) and mitigated the subordinating operation of power in client relationships. These resources were, however, dependent on mutual subscription of religious doctrines, a condition that did not remain stable into the 1960s. (shrink)

. ‘Moving at the speed of life?’ A cultural kinematics of telematic times and corporate values. Cultural Values: Vol. 2, No. 2-3, pp. 320-339.

Thomas Hobbes’ dispute with Dionysius of Halicarnassus over the study of Thucydides’ history allows us to understand both the ancient case for an ennobled public rhetoric and Hobbes’ case against it. Dionysius, concerned with cultivating healthy civic oratory, faced a situation in which Roman rhetoricians were emulating shocking attacks on divine justice such as that found in Thucydides’ Melian dialogue; he attempted to steer orators away from such arguments even as he acknowledged their truth. Hobbes, however, recommends the study of (...) Thucydides’ work for a new kind of political education, one that will benefit from Thucydides’ private, even ‘secret’, instruction, which permits the reader to admit to himself what vanity would otherwise hide from him. (shrink)

Thucydides and Aristophanes, austere historian and ribald comic playwright, lived in an Athens that had, since Themistocles, been moving from a regime of ancestral piety towards a secular empire. Thucydides suggests an agreement between his understanding and that of the pious Nicias — over and against this move. Aristophanes too is a vigorous proponent of peace, and the conclusions of many of his plays appear to suggest or encourage a conservative disposition towards ancestral piety or the rule of ancestral, divine (...) law.While these first impressions are not entirely misleading, a careful examination of the two thinkers’works, with attention to Nicias and the question of the gods, suggests a more complicated and revealing picture. Neither thinker is in agreement with Nicias, who proves to be representative of a fundamental human delusion. Each, however, sees that delusion as inescapable for political life, and so makes his appeal to more serious readers inconspicuously. (shrink)